She was born in an agriculturist family in Madras and was married to Dr. Achanta Laxmipathi. Rukmini was deeply influenced by national leaders like Mahatma Gandhi, Sarojini Naidu and C. Ragopalachari. She joined the congress in 1923 and gave all her jewellery to Harijan Welfare Fund. She actively participated in Salt Satyagraha and had to undergo imprisonment for a year. She was elected to Madras Legislative Assembly in 1937, and served as Health Minister in T. Prakasan Ministry in 1946. She was a great social reformer and worked for the upliftment of women in society. She died on 6-8-1951.